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AstraZeneca takes a £1.5bn stake in US cancer drug developer as it steps up investment in America

Today

The British drugs company has ploughed £1.5bn into US pharma firm Summit Therapeutics as part of a cancer treatment research joint venture.

UK business confidence at 17-month low: Bosses demand Budget 'breathing space'

Today

Business confidence has plunged to a 17-month low in a blow to Andy Burnham after his key party conference speech failed to reassure jittery bond markets.

Burnham's Budget gamble: Labour must get a grip on public spending if Britain is to truly prosper, says ALEX BRUMMER

Today

Far away from Liverpool and Labour delegates full of hope, there was an uncomfortable reminder of the task Andy Burnham faces.

Shein shares crash to record low as profits slump amid Iran fallout

Today

In its first results since listing in Hong Kong on September 1, Shein said second quarter profits were down 66% on a year earlier at £173m.

Del Boy's three-wheeled van from Only Fools and Horses is for sale and could be yours... for £40,000

Today

Fans of the beloved BBC sitcom have a chance to own a piece of 'pukka' TV history when the canary yellow Reliant Regal Supervan III from Only Fools and Horses goes to auction next month.

M&S teams up with makeup giant Sephora to launch across 100 stores in major beauty push

Today

Customers will be able to buy a mix of established and emerging beauty brands and exclusive products across skincare, makeup and fragrance in store and online.

Three major lenders raise mortgage rates as experts warn sub-5% deals are disappearing fast

Today

Households are being hit with a fresh wave of mortgage rate hikes this week as lenders anticipate higher inflation and interest rates.

Councils handed power to seize empty buy-to-lets under Labour plans: What is an EDMO and who could be stung?

Today

The announcement has alarmed some landlords, who worry they could face their property being taken out of their hands. We explain what they need to know.

AI giant Anthropic warns of 'existential risks to humanity' as it targets $2trn stock market debut

Today

The startup behind the Claude tool said its AI models could manipulate, blackmail and exhibit other 'self-preserving behaviours'.

The jobs most at risk of AI... and how you can future-proof your career and finances: JOE MINIHANE lost his livelihood after 25 years and was left struggling to pay the bills. This is his warning to those at risk

Today

In a devastating end to a 25-year writing career, I've officially been replaced by Artificial Intelligence (AI). Company after company has told me my services are no longer required.

Vesuvius becomes latest British firm to confirm takeover bid from foreign rival

Today

British engineering group Vesuvius jumped on Tuesday after it confirmed it had become the latest London-listed firm to be targeted by foreign bidders.

What is the state pension triple lock - and why is it due to rise £902?

Today

Prime Minister Andy Burnham has announced plans to ditch the state pension triple lock in favour of a double lock linked to inflation.

My colleague earns £20k more for a similar job, can I demand a pay rise?

Today

My boss says it's because that's what it cost to get them to move from a rival company, and they are ten years' older with higher earnings built up over a longer career.

North Sea has lost 25,000 jobs under Labour: Industry chiefs demand windfall tax is scrapped

Today

A report from the North Sea Transition Taskforce says a plan to phase out the levy must be brought forward to prevent a 'disorderly decline'.

JD Sports to open more than 140 shops in Mexico as it steps up overseas expansion

Today

A partnership with Grupo Axo, which helps brands grow in Mexico, Chile, Peru and Uruguay, will launch the JD brand in the region.

How City of London investment trust's record-breaking 60 years of dividend rises turned £1,000 into £1.3M

Today

The £3billion City of London investment trust has become the first to increase its annual dividend for sixty years in a row.

Mike Ashley tightens grip on Hugo Boss as son-in-law and Frasers boss is made chairman

Today

Frasers, owned by billionaire Mike Ashley, has tightened its grip on Hugo Boss in recent months. Murray takes over just days after former chairman Stephan Sturm stepped down.

Women face AI 'triple penalty' as jobs wiped out and men dominate growing tech roles

Today

Women face a 'triple penalty' from the rise of artificial intelligence (AI) as many of their jobs are wiped out while men dominate roles created by the new technology.

Angela Rayner's planning reforms are not enough, says Britain's biggest housebuilder, as tax hikes bite

Today

Barratt Redrow said it expected higher mortgage rates and affordability pressures to continue to impact customer confidence in the housing market in the year ahead.

Husband, 94, forced to pay £8,000 a month for his wife's Alzheimer's nursing care - after NHS funding was denied despite her 'severe' needs

Today

Terry Mahoney, 94, from St Albans, must pay £8,000 each month for his wife Barbara's nursing home. Their daughter Tracey Hart told This is Money of the toll it's taking on the family.